Oxford Nanopore Technologies Ltd was founded in 2005 as a spin-out from the University of Oxford. The company now employs about 600 employees from multiple disciplines including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing and commercialisation.

TECHNOLOGY

Oxford Nanopore has developed a new generation of DNA/RNA sequencing technology. It is the only sequencing technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long read lengths.

Small formats such as Flongle address the need for on-demand, rapid, smaller tests or experiments, and can be used in labs or in the field. The pocket-sized MinION is a powerful and portable sequencing device that can deliver high volumes of long read sequence data. The benchtop GridION Mk1 can run up to five MinION Flow Cells at a time, on-demand, for larger genomics projects. PromethION is the largest format for nanopore sequencing, designed to offer on-demand use of up to 48 Flow Cells – capable of delivering more than 10 Tb of sequence data in a full run, and is now being used in population-scale sequencing projects.

To make the technology suitable for any user, we focus on increasing ease of use and automation. Nanopore sequencing offers easy and rapid preparation, including a ten minute library preparation kit and the automated, programmable VolTRAX. We also provide a range of analysis workflows.

Nanopore sequencing, the only technology that offers scientific researchers:

• Sequence any DNA/RNA fragment length from short to ultra-longCharacterise more genetic variation, versatile to broad applications.
• Direct sequencing of native DNA/RNAGenerate content-rich data, including methylation.
• Data available in real timeRapid insights, and analyses that can respond to results in real time.
• Scalable from portable devices to ultra-high throughput desktop devicesSequence anything, anywhere.
• No capital investment requiredAccessible and cost effective.
• Simple & rapid, or automated, library prepEasy to use and versatile.

A. MinION

• Pocket-sized
• Up to 512 nanopore channels
• Simple 10-minute sample prep available
• Many publications illustrate broad usage
• Commercially available

B. GridION

• Multiple sequencing devices, one compute module
• Use up to five MinION Flow Cells at a time
• Benchtop processor capable of handling high data volumes in real time
• Rapid, real-time applications such as Read Until

C. PromethION

• Benchtop system
• Up to 48 flow cells of 3,000 nanopore channels each
• Simple 10-minute sample prep available
• Flow cells may be run individually or concurrently